The Dual Functions of a Bracovirus C-Type Lectin in Caterpillar Immune Response Manipulation

Xiaotong Wu; Xiaotong Wu; Xiaotong Wu; Xiaotong Wu; Zhiwei Wu; Zhiwei Wu; Zhiwei Wu; Xiqian Ye; Xiqian Ye; Xiqian Ye; Xiqian Ye; Lan Pang; Lan Pang; Lan Pang; Yifeng Sheng; Yifeng Sheng; Yifeng Sheng; Zehua Wang; Zehua Wang; Zehua Wang; Yuenan Zhou; Yuenan Zhou; Yuenan Zhou; Jiachen Zhu; Jiachen Zhu; Jiachen Zhu; Rongmin Hu; Rongmin Hu; Rongmin Hu; Sicong Zhou; Sicong Zhou; Sicong Zhou; Jiani Chen; Jiani Chen; Jiani Chen; Zhizhi Wang; Zhizhi Wang; Zhizhi Wang; Zhizhi Wang; Min Shi; Min Shi; Min Shi; Min Shi; Min Shi; Jianhua Huang; Jianhua Huang; Jianhua Huang; Jianhua Huang; Jianhua Huang; Xuexin Chen; Xuexin Chen; Xuexin Chen; Xuexin Chen; Xuexin Chen

doi:10.3389/fimmu.2022.877027

Frontiers in Immunology (May 2022)

The Dual Functions of a Bracovirus C-Type Lectin in Caterpillar Immune Response Manipulation

Xiaotong Wu,
Xiaotong Wu,
Xiaotong Wu,
Xiaotong Wu,
Zhiwei Wu,
Zhiwei Wu,
Zhiwei Wu,
Xiqian Ye,
Xiqian Ye,
Xiqian Ye,
Xiqian Ye,
Lan Pang,
Lan Pang,
Lan Pang,
Yifeng Sheng,
Yifeng Sheng,
Yifeng Sheng,
Zehua Wang,
Zehua Wang,
Zehua Wang,
Yuenan Zhou,
Yuenan Zhou,
Yuenan Zhou,
Jiachen Zhu,
Jiachen Zhu,
Jiachen Zhu,
Rongmin Hu,
Rongmin Hu,
Rongmin Hu,
Sicong Zhou,
Sicong Zhou,
Sicong Zhou,
Jiani Chen,
Jiani Chen,
Jiani Chen,
Zhizhi Wang,
Zhizhi Wang,
Zhizhi Wang,
Zhizhi Wang,
Min Shi,
Min Shi,
Min Shi,
Min Shi,
Min Shi,
Jianhua Huang,
Jianhua Huang,
Jianhua Huang,
Jianhua Huang,
Jianhua Huang,
Xuexin Chen,
Xuexin Chen,
Xuexin Chen,
Xuexin Chen,
Xuexin Chen

Affiliations

Xiaotong Wu: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Xiaotong Wu: Guangdong Lab for Lingnan Modern Agriculture, Guangzhou, China
Xiaotong Wu: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Xiaotong Wu: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Zhiwei Wu: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Zhiwei Wu: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Zhiwei Wu: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Xiqian Ye: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Xiqian Ye: Guangdong Lab for Lingnan Modern Agriculture, Guangzhou, China
Xiqian Ye: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Xiqian Ye: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Lan Pang: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Lan Pang: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Lan Pang: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Yifeng Sheng: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Yifeng Sheng: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Yifeng Sheng: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Zehua Wang: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Zehua Wang: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Zehua Wang: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Yuenan Zhou: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Yuenan Zhou: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Yuenan Zhou: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Jiachen Zhu: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Jiachen Zhu: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Jiachen Zhu: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Rongmin Hu: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Rongmin Hu: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Rongmin Hu: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Sicong Zhou: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Sicong Zhou: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Sicong Zhou: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Jiani Chen: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Jiani Chen: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Jiani Chen: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Zhizhi Wang: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Zhizhi Wang: Guangdong Lab for Lingnan Modern Agriculture, Guangzhou, China
Zhizhi Wang: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Zhizhi Wang: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Min Shi: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Min Shi: Guangdong Lab for Lingnan Modern Agriculture, Guangzhou, China
Min Shi: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Min Shi: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Min Shi: State Key Lab of Rice Biology, Zhejiang University, Hangzhou, China
Jianhua Huang: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Jianhua Huang: Guangdong Lab for Lingnan Modern Agriculture, Guangzhou, China
Jianhua Huang: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Jianhua Huang: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Jianhua Huang: State Key Lab of Rice Biology, Zhejiang University, Hangzhou, China
Xuexin Chen: Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China
Xuexin Chen: Guangdong Lab for Lingnan Modern Agriculture, Guangzhou, China
Xuexin Chen: Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China
Xuexin Chen: Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Zhejiang University, Hangzhou, China
Xuexin Chen: State Key Lab of Rice Biology, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.3389/fimmu.2022.877027
Journal volume & issue: Vol. 13

Abstract

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Parasitoids are widespread in natural ecosystems and normally equipped with diverse viral factors to defeat host immune responses. On the other hand, parasitoids can enhance the antibacterial abilities and improve the hypoimmunity traits of parasitized hosts that may encounter pathogenic infections. These adaptive strategies guarantee the survival of parasitoid offspring, yet their underlying mechanisms are poorly understood. Here, we focused on Cotesia vestalis, an endoparasitoid of the diamondback moth Plutella xylostella, and found that C. vestalis parasitization decreases the number of host hemocytes, leading to disruption of the encapsulation reaction. We further found that one bracovirus C-type lectin gene, CvBV_28-1, is highly expressed in the hemocytes of parasitized hosts and participates in suppressing the proliferation rate of host hemocytes, which in turn reduces their population and represses the process of encapsulation. Moreover, CvBV_28-1 presents a classical bacterial clearance ability via the agglutination response in a Ca2+-dependent manner in response to gram-positive bacteria. Our study provides insights into the innovative strategy of a parasitoid-derived viral gene that has dual functions to manipulate host immunity for a successful parasitism.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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