Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis
Min-Jung Lee,
Yoon Mee Park,
Byunghyun Kim,
in Hwan Tae,
Nam-Eun Kim,
Marina Pranata,
Taewon Kim,
Sungho Won,
Nam Joo Kang,
Yun Kyung Lee,
Dong-Woo Lee,
Myung Hee Nam,
Soo-Jong Hong,
Bong-Soo Kim
Affiliations
Min-Jung Lee
Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea
Yoon Mee Park
Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea
Byunghyun Kim
Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea
in Hwan Tae
Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea
Nam-Eun Kim
Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea
Marina Pranata
Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheonan, Republic of Korea
Taewon Kim
School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea
Sungho Won
Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea
Nam Joo Kang
School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea
Yun Kyung Lee
Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheonan, Republic of Korea
Dong-Woo Lee
Department of Biotechnology, Yonsei University, Seoul, Republic of Korea
Myung Hee Nam
Seoul Center, Korea Basic Science Institute, Seoul, Republic of Korea
Soo-Jong Hong
Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Bong-Soo Kim
Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea
The gut microbiome influences the development of allergic diseases during early childhood. However, there is a lack of comprehensive understanding of microbiome-host crosstalk. Here, we analyzed the influence of gut microbiome dynamics in early childhood on atopic dermatitis (AD) and the potential interactions between host and microbiome that control this homeostasis. We analyzed the gut microbiome in 346 fecal samples (6–36 months; 112 non-AD, 110 mild AD, and 124 moderate to severe AD) from the Longitudinal Cohort for Childhood Origin of Asthma and Allergic Disease birth cohort. The microbiome-host interactions were analyzed in animal and in vitro cell assays. Although the gut microbiome maturated with age in both AD and non-AD groups, its development was disordered in the AD group. Disordered colonization of short-chain fatty acids (SCFA) producers along with age led to abnormal SCFA production and increased IgE levels. A butyrate deficiency and downregulation of GPR109A and PPAR-γ genes were detected in AD-induced mice. Insufficient butyrate decreases the oxygen consumption rate of host cells, which can release oxygen to the gut and perturb the gut microbiome. The disordered gut microbiome development could aggravate balanced microbiome-host interactions, including immune responses during early childhood with AD.
