Nature Communications (Aug 2018)

Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

  • GuanQun Liu,
  • Yao Lu,
  • Sathya N. Thulasi Raman,
  • Fang Xu,
  • Qi Wu,
  • Zhubing Li,
  • Robert Brownlie,
  • Qiang Liu,
  • Yan Zhou

DOI
https://doi.org/10.1038/s41467-018-05745-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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RIG-I senses cytoplasmic viral RNA, resulting in induction of an antiviral response. Here, the authors identify nuclear RIG-I and show that it binds nuclear influenza A virus RNA, resulting in a cooperative interferon induction along with its cytoplasmic counterpart.