Beilstein Journal of Organic Chemistry (Nov 2017)

A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway

  • Dmitry Yu. Vandyshev,
  • Khidmet S. Shikhaliev,
  • Andrey Yu. Potapov,
  • Michael Yu. Krysin,
  • Fedor I. Zubkov,
  • Lyudmila V. Sapronova

DOI
https://doi.org/10.3762/bjoc.13.252
Journal volume & issue
Vol. 13, no. 1
pp. 2561 – 2568

Abstract

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The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-b]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and subsequent intramolecular recyclization of the intermediate with the amino group involved.

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