Nature Communications (Feb 2020)
Caspase-11 promotes allergic airway inflammation
- Zbigniew Zasłona,
- Ewelina Flis,
- Mieszko M. Wilk,
- Richard G. Carroll,
- Eva M. Palsson-McDermott,
- Mark M. Hughes,
- Ciana Diskin,
- Kathy Banahan,
- Dylan G. Ryan,
- Alexander Hooftman,
- Alicja Misiak,
- Jay Kearney,
- Gunter Lochnit,
- Wilhelm Bertrams,
- Timm Greulich,
- Bernd Schmeck,
- Oliver J. McElvaney,
- Kingston H. G. Mills,
- Ed C. Lavelle,
- Małgorzata Wygrecka,
- Emma M. Creagh,
- Luke A. J. O’Neill
Affiliations
- Zbigniew Zasłona
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Ewelina Flis
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Mieszko M. Wilk
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Richard G. Carroll
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Eva M. Palsson-McDermott
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Mark M. Hughes
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Ciana Diskin
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Kathy Banahan
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Dylan G. Ryan
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Alexander Hooftman
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Alicja Misiak
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Jay Kearney
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Gunter Lochnit
- Department of Biochemistry, Faculty of Medicine, Justus Liebig University
- Wilhelm Bertrams
- Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL)
- Timm Greulich
- Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL)
- Bernd Schmeck
- Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL)
- Oliver J. McElvaney
- Royal College of Surgeons in Ireland, Beaumont Hospital
- Kingston H. G. Mills
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Ed C. Lavelle
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Małgorzata Wygrecka
- Department of Biochemistry, Faculty of Medicine, Justus Liebig University
- Emma M. Creagh
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- Luke A. J. O’Neill
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin
- DOI
- https://doi.org/10.1038/s41467-020-14945-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, and that mice lacking caspase-11 are strongly protected from allergic airway inflammation.
