Pancreatic mixed acinar-neuroendocrine carcinoma with intraductal growth: A case report with radiologic–pathologic correlations

Hiroshi Baba, MD; Yasunari Yamada, MD; Kazuhiro Tada, MD; Yusuke Kuboyama, MD; Kengo Fukuzawa, MD; Kentaro Iwaki, MD; Mitsuteru Motomura, MD; Ryo Takaji, MD; Ryuichi Shimada, MD; Hajime Takaki, MD; Yoshiki Asayama, MD

Radiology Case Reports (Dec 2023)

Pancreatic mixed acinar-neuroendocrine carcinoma with intraductal growth: A case report with radiologic–pathologic correlations

Hiroshi Baba, MD,
Yasunari Yamada, MD,
Kazuhiro Tada, MD,
Yusuke Kuboyama, MD,
Kengo Fukuzawa, MD,
Kentaro Iwaki, MD,
Mitsuteru Motomura, MD,
Ryo Takaji, MD,
Ryuichi Shimada, MD,
Hajime Takaki, MD,
Yoshiki Asayama, MD

Affiliations

Hiroshi Baba, MD: Department of Radiology, Oita Red Cross Hospital, Chiyo-machi, Oita, Japan
Yasunari Yamada, MD: Department of Radiology, Oita Red Cross Hospital, Chiyo-machi, Oita, Japan; Corresponding author.
Kazuhiro Tada, MD: Department of Surgery, Oita Red Cross Hospital, Chiyo-machi, Oita , Japan
Yusuke Kuboyama, MD: Department of Pathology, Oita Red Cross Hospital, Chiyo-machi, Oita, Japan
Kengo Fukuzawa, MD: Department of Surgery, Oita Red Cross Hospital, Chiyo-machi, Oita , Japan
Kentaro Iwaki, MD: Department of Surgery, Oita Red Cross Hospital, Chiyo-machi, Oita , Japan
Mitsuteru Motomura, MD: Hepato-Biliary-Pancreatic Internal Medicine, Oita Red Cross Hospital, Chiyo-machi, Oita, 870-0033, Japan
Ryo Takaji, MD: Department of Radiology, Oita University Faculty of Medicine, Yufu, Oita, 879-5593, Japan
Ryuichi Shimada, MD: Department of Radiology, Oita University Faculty of Medicine, Yufu, Oita, 879-5593, Japan
Hajime Takaki, MD: Department of Radiology, Oita Red Cross Hospital, Chiyo-machi, Oita, Japan
Yoshiki Asayama, MD: Department of Radiology, Oita University Faculty of Medicine, Yufu, Oita, 879-5593, Japan

Journal volume & issue: Vol. 18, no. 12
pp. 4422 – 4430

Abstract

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Pancreatic mixed acinar-neuroendocrine carcinomas are rare malignant tumors of the pancreas. They are composed histologically of both acinar and neuroendocrine cells. The pancreatic duct is known to be an important site of tumor growth for acinar cell carcinomas, neuroendocrine tumors, and intraductal tubulopapillary neoplasms. To the best of our knowledge, there has been only 1 report of a mixed acinar-neuroendocrine carcinoma growing into the pancreatic duct and no reports detailing imaging findings with this tumor. We here report a 69-year-old man who presented with worsening glycemic control. Multiphase contrast-enhanced computed tomography and magnetic resonance imaging revealed a well-circumscribed mass with poor contrast enhancement in the pancreatic tail region of the pancreatic duct. The intraductal mass showed diffusion restriction on magnetic resonance imaging. These imaging findings are consistent with the expansive, smooth-surfaced polypoid tumor of low vascularity and high cellularity that was diagnosed pathologically. Mixed acinar-neuroendocrine carcinomas should be included in the differential diagnosis of intraductal tumors of the pancreas with poor contrast enhancement and diffusion restriction.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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