Nature Communications (Aug 2021)
Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
- Juozas Gordevicius,
- Peipei Li,
- Lee L. Marshall,
- Bryan A. Killinger,
- Sean Lang,
- Elizabeth Ensink,
- Nathan C. Kuhn,
- Wei Cui,
- Nazia Maroof,
- Roberta Lauria,
- Christina Rueb,
- Juliane Siebourg-Polster,
- Pierre Maliver,
- Jared Lamp,
- Irving Vega,
- Fredric P. Manfredsson,
- Markus Britschgi,
- Viviane Labrie
Affiliations
- Juozas Gordevicius
- Center for Neurodegenerative Science, Van Andel Institute
- Peipei Li
- Center for Neurodegenerative Science, Van Andel Institute
- Lee L. Marshall
- Center for Neurodegenerative Science, Van Andel Institute
- Bryan A. Killinger
- Center for Neurodegenerative Science, Van Andel Institute
- Sean Lang
- Center for Neurodegenerative Science, Van Andel Institute
- Elizabeth Ensink
- Center for Neurodegenerative Science, Van Andel Institute
- Nathan C. Kuhn
- Department of Translational Neuroscience, College of Human Medicine, Michigan State University
- Wei Cui
- Center for Epigenetics, Van Andel Institute
- Nazia Maroof
- Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center, Basel, F. Hoffmann-La Roche Ltd
- Roberta Lauria
- Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center, Basel, F. Hoffmann-La Roche Ltd
- Christina Rueb
- Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center, Basel, F. Hoffmann-La Roche Ltd
- Juliane Siebourg-Polster
- Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd
- Pierre Maliver
- Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd
- Jared Lamp
- Department of Translational Neuroscience, College of Human Medicine, Michigan State University
- Irving Vega
- Department of Translational Neuroscience, College of Human Medicine, Michigan State University
- Fredric P. Manfredsson
- Department of Translational Neuroscience, College of Human Medicine, Michigan State University
- Markus Britschgi
- Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center, Basel, F. Hoffmann-La Roche Ltd
- Viviane Labrie
- Center for Neurodegenerative Science, Van Andel Institute
- DOI
- https://doi.org/10.1038/s41467-021-25474-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’s disease.
