Fixed combination drug therapy as an opportunity to improve the efficacy and safety of the conventional back pain treatment

Abstract

According to statistics, 70–90% of the population suffer from back pain, however, despite the enormous efforts to find ways of improving the efficacy and safety of therapy for patients with dorsalgia, and the diversity of therapeutic options, numerous challenges and issues related to the pain syndrome therapy have not been addressed. The nonsteroidal anti-inflammatory drugs (NSAIDs), having both anti-inflammatory and analgesic effects, are conventionally and most commonly used to treat back pain. However, the use of these medications is associated with the development of a rather broad range of adverse effects. The paper considers the opportunity of using the drug combination therapy with the inclusion of medications, capable of improving the NSAID efficacy and reduce the adverse reactions to NSAIDs. The results of studying the efficacy of the B vitamin combination and the combination of B vitamins with NSAID in treatment of patients with dorsalgia are reviewed.

Keywords

• dorsalgia
• back pain
• b vitamins
• nonsteroidal anti-inflammatory drugs