An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China

Meiling Zhang; Zhixiao Chen; Jienan Zhou; Xiaonan Zhao; Yaoyao Chen; Yanhong Sun; Zhaosheng Liu; Wenpeng Gu; Chunrui Luo; Xiaoqing Fu; Xiang Zhao

Biosafety and Health (Dec 2022)

An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China

Meiling Zhang,
Zhixiao Chen,
Jienan Zhou,
Xiaonan Zhao,
Yaoyao Chen,
Yanhong Sun,
Zhaosheng Liu,
Wenpeng Gu,
Chunrui Luo,
Xiaoqing Fu,
Xiang Zhao

Affiliations

Meiling Zhang: Yunnan Center for Disease Control and Prevention, Kunming 650022, China; Corresponding authors: Yunnan Center for Disease Control and Prevention, Kunming 650022, China (M. Zhang and X. Fu); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Zhao).
Zhixiao Chen: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Jienan Zhou: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Xiaonan Zhao: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Yaoyao Chen: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Yanhong Sun: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Zhaosheng Liu: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Wenpeng Gu: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Chunrui Luo: Yunnan Center for Disease Control and Prevention, Kunming 650022, China
Xiaoqing Fu: Yunnan Center for Disease Control and Prevention, Kunming 650022, China; Corresponding authors: Yunnan Center for Disease Control and Prevention, Kunming 650022, China (M. Zhang and X. Fu); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Zhao).
Xiang Zhao: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Corresponding authors: Yunnan Center for Disease Control and Prevention, Kunming 650022, China (M. Zhang and X. Fu); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Zhao).

Journal volume & issue: Vol. 4, no. 6
pp. 406 – 409

Abstract

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The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future.

Published in Biosafety and Health

ISSN: 2590-0536 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/biosafety-and-health/

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