Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
Maria Antonia De Francesco,
Giovanni Ianiro,
Marina Monini,
Cesare Vezzoli,
Richard Fabian Schumacher,
Silvia Giliani,
Giovanni Lorenzin,
Francesca Gurrieri,
Arnaldo Caruso
Affiliations
Maria Antonia De Francesco
Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, 25123 Brescia, Italy
Giovanni Ianiro
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy
Marina Monini
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy
Cesare Vezzoli
Pediatric Intensive Care Unit, Children’s Hospital, ASST-Spedali Civili, 25123 Brescia, Italy
Richard Fabian Schumacher
Haemato-oncology and BMT Unit, Children’s Hospital, ASST-Spedali Civili, 25123 Brescia, Italy
Silvia Giliani
A. Nocivelli Institute for Molecular Medicine, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy
Giovanni Lorenzin
Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, 25123 Brescia, Italy
Francesca Gurrieri
Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, 25123 Brescia, Italy
Arnaldo Caruso
Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, 25123 Brescia, Italy
We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolved after complete immune reconstitution achieved by hematopoietic stem cell transplantation. This case underlines the importance of neonatal SCID_screening.
