Frontiers in Cell and Developmental Biology (Jun 2023)

Epigenetic modification in Parkinson’s disease

  • Hao Song,
  • Hao Song,
  • Juanli Chen,
  • Jin Huang,
  • Peng Sun,
  • Yanming Liu,
  • Li Xu,
  • Chuanfei Wei,
  • Xin Mu,
  • Xianjie Lu,
  • Wei Wang,
  • Nan Zhang,
  • Miwei Shang,
  • Mei Mo,
  • Wei Zhang,
  • Hui Zhao,
  • Fabin Han,
  • Fabin Han

DOI
https://doi.org/10.3389/fcell.2023.1123621
Journal volume & issue
Vol. 11

Abstract

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Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD. In this review, we discuss current understanding of the epigenetic mechanisms that regulate gene expression and neural degeneration and then highlight emerging epigenetic targets and diagnostic and therapeutic biomarkers for treating or preventing PD.

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