Frontiers in Medicine (Aug 2021)
Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
- Penélope Saldanha Marinho,
- Antonio José Ledo Alves da Cunha,
- Antonio José Ledo Alves da Cunha,
- Leila Chimelli,
- Elyzabeth Avvad-Portari,
- Elyzabeth Avvad-Portari,
- Felipe da Matta Andreiuolo,
- Patrícia Soares de Oliveira-Szejnfeld,
- Patrícia Soares de Oliveira-Szejnfeld,
- Mayara Abud Mendes,
- Ismael Carlos Gomes,
- Ismael Carlos Gomes,
- Letícia Rocha Q. Souza,
- Marilia Zaluar Guimarães,
- Marilia Zaluar Guimarães,
- Suzan Menasce Goldman,
- Mariana Barros Genuíno de Oliveira,
- Stevens Rehen,
- Stevens Rehen,
- Joffre Amim,
- Fernanda Tovar-Moll,
- Fernanda Tovar-Moll,
- Arnaldo Prata-Barbosa,
- Arnaldo Prata-Barbosa
Affiliations
- Penélope Saldanha Marinho
- Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Antonio José Ledo Alves da Cunha
- Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Antonio José Ledo Alves da Cunha
- Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Leila Chimelli
- Laboratory of Neuropathology, Rio de Janeiro State Brain Institute, Rio de Janeiro, Brazil
- Elyzabeth Avvad-Portari
- Department of Pathological Anatomy, Fernandes Figueira Institute, Fiocruz, Rio de Janeiro, Brazil
- Elyzabeth Avvad-Portari
- School of Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil
- Felipe da Matta Andreiuolo
- Laboratory of Neuropathology, Rio de Janeiro State Brain Institute, Rio de Janeiro, Brazil
- Patrícia Soares de Oliveira-Szejnfeld
- Diagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
- Patrícia Soares de Oliveira-Szejnfeld
- Diagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Mayara Abud Mendes
- Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Ismael Carlos Gomes
- Genetics Department, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Ismael Carlos Gomes
- 0Anatomic Pathology Service, Jesus Municipal Hospital, Rio de Janeiro, Brazil
- Letícia Rocha Q. Souza
- Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Marilia Zaluar Guimarães
- Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Marilia Zaluar Guimarães
- 1Department of Phamacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Suzan Menasce Goldman
- Diagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
- Mariana Barros Genuíno de Oliveira
- Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Stevens Rehen
- Diagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Stevens Rehen
- Stem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Joffre Amim
- Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Fernanda Tovar-Moll
- Diagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil
- Fernanda Tovar-Moll
- Diagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- Arnaldo Prata-Barbosa
- Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Arnaldo Prata-Barbosa
- Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil
- DOI
- https://doi.org/10.3389/fmed.2021.677001
- Journal volume & issue
-
Vol. 8
Abstract
SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.
Keywords
