Molecules (Feb 2012)

A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

  • Jingquan Yuan,
  • Mingliang Zhong,
  • Xudong Xu,
  • Junshan Yang,
  • Guangli Sun,
  • Xiaopo Zhang

DOI
https://doi.org/10.3390/molecules17021883
Journal volume & issue
Vol. 17, no. 2
pp. 1883 – 1889

Abstract

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On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 µg/mL and 73.9 µg/mL.

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