Risk factors and the possibility of predicting late premature birth

Abstract

In the structure of preterm labor, more than half of the cases occur in late preterm labor. Many aspects of this problem remain unexplored. The article analyzes the literature sources from 2018 to 2023 (domestic and foreign scientific studies, meta-analyses, and systematic reviews) devoted to late premature birth. Risk factors, prognosis, and management strategies for preterm birth in the period from 34 to 36 weeks of pregnancy are considered. Understanding risk factors and predictive capabilities are important to prevent late pregnancy and improve pregnancy outcomes. For ease of use, risk factors and prognostic criteria are summarized in tables with references and OR. Based on the analyzed data, an approximate portrait of a patient with late premature birth was compiled and the value of biochemical markers (PAMG-1 and fibronectin), as well as instrumental methods - cervicometry and elastography ultrasound examination of the cervix, as the most informative predictor tests of the onset of late preterm birth was confirmed. It seems optimal to assess risks using several methods for predicting the onset of premature birth. The information provided in this article allows for a correct assessment of the risks of premature birth, including late delivery, and to determine management tactics based on the use of informative and "fast" tests for threatening deliveries, which will improve their outcomes.

Keywords

• late premature birth
• labor
• risk factors
• prognosis
• biomarkers
• cervicometry
• elastography
• childbirth at 34–36 weeks of pregnancy