Cancers (May 2021)
International Multi-Site Initiative to Develop an MRI-Inclusive Nomogram for Side-Specific Prediction of Extraprostatic Extension of Prostate Cancer
- Andreas G. Wibmer,
- Michael W. Kattan,
- Francesco Alessandrino,
- Alexander D. J. Baur,
- Lars Boesen,
- Felipe Boschini Franco,
- David Bonekamp,
- Riccardo Campa,
- Hannes Cash,
- Violeta Catalá,
- Sebastien Crouzet,
- Sounil Dinnoo,
- James Eastham,
- Fiona M. Fennessy,
- Kamyar Ghabili,
- Markus Hohenfellner,
- Angelique W. Levi,
- Xinge Ji,
- Vibeke Løgager,
- Daniel J. Margolis,
- Paul C. Moldovan,
- Valeria Panebianco,
- Tobias Penzkofer,
- Philippe Puech,
- Jan Philipp Radtke,
- Olivier Rouvière,
- Heinz-Peter Schlemmer,
- Preston C. Sprenkle,
- Clare M. Tempany,
- Joan C. Vilanova,
- Jeffrey Weinreb,
- Hedvig Hricak,
- Amita Shukla-Dave
Affiliations
- Andreas G. Wibmer
- Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
- Michael W. Kattan
- Department of Quantitative Health Sciences in the Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
- Francesco Alessandrino
- Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
- Alexander D. J. Baur
- Charité University Hospital, 10117 Berlin, Germany
- Lars Boesen
- Herlev Gentofte University Hospital, 2730 Herlev, Denmark
- Felipe Boschini Franco
- Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
- David Bonekamp
- DKFZ German Cancer Research Center, 69120 Heidelberg, Germany
- Riccardo Campa
- Department of Radiological Sciences, Oncology & Pathology, Sapienza University of Rome, 00185 Rome, Italy
- Hannes Cash
- Charité University Hospital, 10117 Berlin, Germany
- Violeta Catalá
- Department of Radiology, Fundació Puigvert, 08025 Barcelona, Spain
- Sebastien Crouzet
- Hospices Civils de Lyon, Hôpital Edouard Herriot, 69003 Lyon, France
- Sounil Dinnoo
- Genitourinary and Women’s Imaging Departments, Lille University Hospital, 59037 Lille, France
- James Eastham
- Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- Fiona M. Fennessy
- Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
- Kamyar Ghabili
- Department of Urology, Yale School of Medicine, New Haven, CT 06510, USA
- Markus Hohenfellner
- Department of Urology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
- Angelique W. Levi
- Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA
- Xinge Ji
- Department of Quantitative Health Sciences in the Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
- Vibeke Løgager
- Herlev Gentofte University Hospital, 2730 Herlev, Denmark
- Daniel J. Margolis
- Weill Cornell Medicine, Weill Cornell Imaging, New York-Presbyterian Hospital, New York, NY 10021, USA
- Paul C. Moldovan
- Hospices Civils de Lyon, Hôpital Edouard Herriot, 69003 Lyon, France
- Valeria Panebianco
- Department of Radiological Sciences, Oncology & Pathology, Sapienza University of Rome, 00185 Rome, Italy
- Tobias Penzkofer
- Charité University Hospital, 10117 Berlin, Germany
- Philippe Puech
- Genitourinary and Women’s Imaging Departments, Lille University Hospital, 59037 Lille, France
- Jan Philipp Radtke
- DKFZ German Cancer Research Center, 69120 Heidelberg, Germany
- Olivier Rouvière
- Hospices Civils de Lyon, Hôpital Edouard Herriot, 69003 Lyon, France
- Heinz-Peter Schlemmer
- DKFZ German Cancer Research Center, 69120 Heidelberg, Germany
- Preston C. Sprenkle
- Department of Urology, Yale School of Medicine, New Haven, CT 06510, USA
- Clare M. Tempany
- Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
- Joan C. Vilanova
- Clínica Girona, Institute Catalan of Health-IDI, University of Girona, 17004 Girona, Spain
- Jeffrey Weinreb
- Department of Radiology, Yale School of Medicine, New Haven, CT 06510, USA
- Hedvig Hricak
- Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
- Amita Shukla-Dave
- Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
- DOI
- https://doi.org/10.3390/cancers13112627
- Journal volume & issue
-
Vol. 13,
no. 11
p. 2627
Abstract
Background: To develop an international, multi-site nomogram for side-specific prediction of extraprostatic extension (EPE) of prostate cancer based on clinical, biopsy, and magnetic resonance imaging- (MRI) derived data. Methods: Ten institutions from the USA and Europe contributed clinical and side-specific biopsy and MRI variables of consecutive patients who underwent prostatectomy. A logistic regression model was used to develop a nomogram for predicting side-specific EPE on prostatectomy specimens. The performance of the statistical model was evaluated by bootstrap resampling and cross validation and compared with the performance of benchmark models that do not incorporate MRI findings. Results: Data from 840 patients were analyzed; pathologic EPE was found in 320/840 (31.8%). The nomogram model included patient age, prostate-specific antigen density, side-specific biopsy data (i.e., Gleason grade group, percent positive cores, tumor extent), and side-specific MRI features (i.e., presence of a PI-RADSv2 4 or 5 lesion, level of suspicion for EPE, length of capsular contact). The area under the receiver operating characteristic curve of the new, MRI-inclusive model (0.828, 95% confidence limits: 0.805, 0.852) was significantly higher than that of any of the benchmark models (p < 0.001 for all). Conclusions: In an international, multi-site study, we developed an MRI-inclusive nomogram for the side-specific prediction of EPE of prostate cancer that demonstrated significantly greater accuracy than clinical benchmark models.
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