Accidental Consumption of Distinguished Substance in Disguise- A Rare Case of Minoxidil Poisoning

Abstract

Minoxidil is a powerful direct acting vasodilator that was used clinically as an oral antihypertensive drug in combination with beta blockers and diuretics in cases of hypertension refractory to other antihypertensives. A 58-year-old male presented to the Emergency Department with an alleged history of accidental consumption of around 10 mL of 5% topical minoxidil solution. He had developed tachycardia, severe hypotension, and characteristic Electrocardiogram (ECG) changes with no obvious chest pain. He was treated with continuous intravenous (i.v.) crystalloids, dual inotropes and other supportive measures. The patient also developed acute pulmonary oedema and acute kidney injury. He responded to treatment and gradually improved haemodynamically with resolution of ECG changes and acute kidney injury. He was discharged seven days after admission. The patient showed resolution of characteristic ECG changes and improvement in haemodynamic condition of patient with supportive management in hospital.

Keywords

• arrhythmias
• haemodynamic instability
• toxicity