Diabetes, Metabolic Syndrome and Obesity (Jul 2021)
Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
Abstract
Shidong Tan,1 Guangyao Zang,1 Ying Wang,1 Zhen Sun,1 Yalan Li,1 Cheng Lu,2 Zhongqun Wang1 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2General Office, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of ChinaCorrespondence: Cheng LuGeneral Office, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, 212001, People’s Republic of China, +86 511 88986902Email [email protected] WangDepartment of Cardiology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, 212001, People’s Republic of ChinaTel +86 511 85030586Email [email protected]: Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.Keywords: diabetes mellitus, tumor, angiogenesis, differences, tumor microenvironment, hypoxia
