Human pancreatic beta-like cells converted from fibroblasts

Saiyong Zhu; Holger A. Russ; Xiaojing Wang; Mingliang Zhang; Tianhua Ma; Tao Xu; Shibing Tang; Matthias Hebrok; Sheng Ding

doi:10.1038/ncomms10080

Nature Communications (Jan 2016)

Human pancreatic beta-like cells converted from fibroblasts

Saiyong Zhu,
Holger A. Russ,
Xiaojing Wang,
Mingliang Zhang,
Tianhua Ma,
Tao Xu,
Shibing Tang,
Matthias Hebrok,
Sheng Ding

Affiliations

Saiyong Zhu: Gladstone Institute of Cardiovascular Disease, University of California
Holger A. Russ: Department of Medicine, Diabetes Center, University of California, San Francisco
Xiaojing Wang: Gladstone Institute of Cardiovascular Disease, University of California
Mingliang Zhang: Gladstone Institute of Cardiovascular Disease, University of California
Tianhua Ma: Gladstone Institute of Cardiovascular Disease, University of California
Tao Xu: Gladstone Institute of Cardiovascular Disease, University of California
Shibing Tang: Gladstone Institute of Cardiovascular Disease, University of California
Matthias Hebrok: Department of Medicine, Diabetes Center, University of California, San Francisco
Sheng Ding: Gladstone Institute of Cardiovascular Disease, University of California

DOI: https://doi.org/10.1038/ncomms10080
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Insulin-producing pancreatic beta cells, generatedin vitro, could lead to new anti-diabetic therapies. Here, Zhu et al. convert human fibroblasts into endodermal progenitors that differentiate in vitrointo glucose-responsive beta-like cells that, following transplantation in mice, protect from diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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