Nature Communications (Jan 2023)
Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis
- Julien Broséus,
- Sébastien Hergalant,
- Julia Vogt,
- Eugen Tausch,
- Markus Kreuz,
- Anja Mottok,
- Christof Schneider,
- Caroline Dartigeas,
- Damien Roos-Weil,
- Anne Quinquenel,
- Charline Moulin,
- German Ott,
- Odile Blanchet,
- Cécile Tomowiak,
- Grégory Lazarian,
- Pierre Rouyer,
- Emil Chteinberg,
- Stephan H. Bernhart,
- Olivier Tournilhac,
- Guillaume Gauchotte,
- Sandra Lomazzi,
- Elise Chapiro,
- Florence Nguyen-Khac,
- Céline Chery,
- Frédéric Davi,
- Mathilde Hunault,
- Rémi Houlgatte,
- Andreas Rosenwald,
- Alain Delmer,
- David Meyre,
- Marie-Christine Béné,
- Catherine Thieblemont,
- Peter Lichter,
- Ole Ammerpohl,
- Jean-Louis Guéant,
- ICGC MMML-Seq Consortium,
- Romain Guièze,
- José Ignacio Martin-Subero,
- Florence Cymbalista,
- Pierre Feugier,
- Reiner Siebert,
- Stephan Stilgenbauer
Affiliations
- Julien Broséus
- Division of CLL. Department of Internal Medicine III, Ulm University
- Sébastien Hergalant
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Julia Vogt
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Eugen Tausch
- Division of CLL. Department of Internal Medicine III, Ulm University
- Markus Kreuz
- Fraunhofer Institute for Cell Therapy and Immunology IZI
- Anja Mottok
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Christof Schneider
- Division of CLL. Department of Internal Medicine III, Ulm University
- Caroline Dartigeas
- Department of Haematology, University Hospital of Tours
- Damien Roos-Weil
- Department of Hematology, Hôpital de la Pitié-Salpêtrière, AP-HP
- Anne Quinquenel
- Université de Reims Champagne-Ardenne, IRMAIC, Centre Hospitalier Universitaire de Reims, Hématologie Clinique
- Charline Moulin
- Department of Hematology, University Hospital of Nancy
- German Ott
- Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology
- Odile Blanchet
- CHU Angers, Biological Resource Center of Angers (CRB-CHU Angers), BB-0033-00038, Laboratoire d’Hématologie
- Cécile Tomowiak
- Department of Hematology, CHU Poitiers
- Grégory Lazarian
- Hematology Laboratory, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris
- Pierre Rouyer
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Emil Chteinberg
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Stephan H. Bernhart
- Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, Leipzig University
- Olivier Tournilhac
- Hematology department, Clermont-Ferrand University Hospital
- Guillaume Gauchotte
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Sandra Lomazzi
- Biological Resource Center of Nancy, BB-0033-00035, CHRU de Nancy
- Elise Chapiro
- Sorbonne Université, Cytogénétique Hématologique, Hôpital Pitié-Salpêtrière, AP-HP
- Florence Nguyen-Khac
- Sorbonne Université, Cytogénétique Hématologique, Hôpital Pitié-Salpêtrière, AP-HP
- Céline Chery
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Frédéric Davi
- Centre de Recherche des Cordeliers, INSERM, Université Sorbonne Paris Cite, Université Paris Descartes, Université Paris Diderot
- Mathilde Hunault
- Department of Hematology, University Hospital of Angers
- Rémi Houlgatte
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Andreas Rosenwald
- Institute of Pathology, University Hospital of Würzburg
- Alain Delmer
- Université de Reims Champagne-Ardenne, IRMAIC, Centre Hospitalier Universitaire de Reims, Hématologie Clinique
- David Meyre
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Marie-Christine Béné
- Hematology Biology, University Hospital of Nantes
- Catherine Thieblemont
- Department of Hematology, Hôpital Saint-Louis
- Peter Lichter
- Division of Molecular Genetics, German Cancer Consortium (DKTK) and National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ)
- Ole Ammerpohl
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Jean-Louis Guéant
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- ICGC MMML-Seq Consortium
- Romain Guièze
- Hematology department, Clermont-Ferrand University Hospital
- José Ignacio Martin-Subero
- Biomedical Epigenomics Group, Institut d’investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona
- Florence Cymbalista
- Hematology Laboratory, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris
- Pierre Feugier
- Inserm UMRS1256 Nutrition-Génétique et Exposition aux Risques Environnementaux (N-GERE), Université de Lorraine
- Reiner Siebert
- Institute of Human Genetics, Ulm University & Ulm University Medical Center
- Stephan Stilgenbauer
- Division of CLL. Department of Internal Medicine III, Ulm University
- DOI
- https://doi.org/10.1038/s41467-022-34642-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Richter syndrome (RS) is the transformation of chronic lymphocytic leukaemia (CLL) into aggressive lymphoma, in most cases diffuse large B-cell lymphoma (DLBCL). Here, the authors characterize the DNA methylation and transcriptomic profiles of RS samples, find a clonally-related CLL epigenetic imprint, and develop classifiers for “RS-type” de novo DLBCLs.
