Emerging Biomarkers for Predicting Bladder Cancer Lymph Node Metastasis

Chunyu Zhang; Jiao Hu; Huihuang Li; Hongzhi Ma; Belaydi Othmane; Wenbiao Ren; Wenbiao Ren; Zhenglin Yi; Dongxu Qiu; Zhenyu Ou; Jinbo Chen; Xiongbing Zu

doi:10.3389/fonc.2021.648968

Frontiers in Oncology (Mar 2021)

Emerging Biomarkers for Predicting Bladder Cancer Lymph Node Metastasis

Chunyu Zhang,
Jiao Hu,
Huihuang Li,
Hongzhi Ma,
Belaydi Othmane,
Wenbiao Ren,
Wenbiao Ren,
Zhenglin Yi,
Dongxu Qiu,
Zhenyu Ou,
Jinbo Chen,
Xiongbing Zu

Affiliations

Chunyu Zhang: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Jiao Hu: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Huihuang Li: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Hongzhi Ma: Department of Radiation Oncology, Hunan Cancer Hospital, Central South University, Changsha, China
Belaydi Othmane: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Wenbiao Ren: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Wenbiao Ren: George Whipple Lab for Cancer Research, University of Rochester Medical Institute, Rochester, NY, United States
Zhenglin Yi: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Dongxu Qiu: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Zhenyu Ou: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Jinbo Chen: Department of Urology, Xiangya Hospital, Central South University, Changsha, China
Xiongbing Zu: Department of Urology, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fonc.2021.648968
Journal volume & issue: Vol. 11

Abstract

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Bladder cancer is one of the leading causes of cancer deaths worldwide. Early detection of lymph node metastasis of bladder cancer is essential to improve patients’ prognosis and overall survival. Current diagnostic methods are limited, so there is an urgent need for new specific biomarkers. Non-coding RNA and m6A have recently been reported to be abnormally expressed in bladder cancer related to lymph node metastasis. In this review, we tried to summarize the latest knowledge about biomarkers, which predict lymph node metastasis in bladder cancer and their mechanisms. In particular, we paid attention to the impact of non-coding RNA on lymphatic metastasis of bladder cancer and its specific molecular mechanisms, as well as some prediction models based on imaging, pathology, and biomolecules, in an effort to find more accurate diagnostic methods for future clinical application.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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