Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Affiliations

Mekheimer Ramadan Ahmed: Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
Hayallah Alaa M.: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt
Moustafa Moustafa Sherief: Department of Chemistry, Faculty of Science, Kuwait University, P. O. Box 12613, Safat 13060, Kuwait
Al-Mousawi Saleh Mohammed: Department of Chemistry, Faculty of Science, Kuwait University, P. O. Box 12613, Safat 13060, Kuwait
Abd-Elmonem Mohamed: Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
Mostafa Sara M.: Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
Abo Elsoud Fatma A.: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt
Sadek Kamal Usef: Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt

Abstract

A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.