Communications Biology (Apr 2022)

SimiC enables the inference of complex gene regulatory dynamics across cell phenotypes

  • Jianhao Peng,
  • Guillermo Serrano,
  • Ian M. Traniello,
  • Maria E. Calleja-Cervantes,
  • Ullas V. Chembazhi,
  • Sushant Bangru,
  • Teresa Ezponda,
  • Juan Roberto Rodriguez-Madoz,
  • Auinash Kalsotra,
  • Felipe Prosper,
  • Idoia Ochoa,
  • Mikel Hernaez

DOI
https://doi.org/10.1038/s42003-022-03319-7
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 19

Abstract

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SimiC, a single-cell gene regulatory inference framework is presented that can infer multiple gene regulatory networks across related cell phenotypes, unraveling complex regulatory dynamics.