Nature Communications (Nov 2021)

Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis

  • Pengcheng Qian,
  • Haixing Guan,
  • Yan-En Wang,
  • Qianqian Lu,
  • Fan Zhang,
  • Dan Xiong,
  • Patrick J. Walsh,
  • Jianyou Mao

DOI
https://doi.org/10.1038/s41467-021-26794-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Enantioenriched α-aryl propionic acids are an important class of nonsteroidal anti-inflammatory medications. Here the authors use a visible-light-promoted photoredox/nickel catalyzed method to form such compunds via a three-component alkyl arylation of acrylates.