Experimental Hematology & Oncology (Sep 2022)

Novel treatment combining antiviral and neutralizing antibody-based therapies with monitoring of spike-specific antibody and viral load for immunocompromised patients with persistent COVID-19 infection

  • Daiki Wada,
  • Yasushi Nakamori,
  • Shuhei Maruyama,
  • Haruka Shimazu,
  • Fukuki Saito,
  • Kazuhisa Yoshiya,
  • Yasuyuki Kuwagata

DOI
https://doi.org/10.1186/s40164-022-00307-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 4

Abstract

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Abstract Because prolonged viral replication of SARS-CoV-2 is increasingly being recognized among immunocompromised patients, subacute or chronic COVID-19 pneumonia can cause persistent lung damage and may lead to viral escape phenomena. Highly efficacious antiviral therapies in immunosuppressed hosts with COVID-19 are urgently needed. From February 2022, we introduced novel treatment combining antiviral therapies and neutralizing antibodies with frequent monitoring of spike-specific antibody and RT-PCR cycle threshold (Ct) values as indicators of viral load for immunocompromised patients with persistent COVID-19 infection. We applied this treatment to 10 immunosuppressed patients with COVID-19, and all completed treatment without relapse of infection. This may be a potentially successful treatment strategy that enables us to sustain viral clearance, determine optimal timing to stop treatment, and prevent virus reactivation in immunocompromised patients with persistent COVID-19.

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