Myometrial oxidative stress drives MED12 mutations in leiomyoma

Abstract

Highlights High rate of MED12 mutations and leiomyoma burden are clearly associated with myometrial oxidative stress. MED12 mutations are driven by misrepair of 8-OHdG at c.130-c.131 detected by deep sequencing analysis both in vitro and in vivo.

Keywords

• Leiomyoma
• MED12 mutation
• Myometrium
• Reactive oxidative species (ROS)
• 8-OHdG
• Duplex sequencing