Communications Biology (Sep 2022)

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

  • Masahiro Nishida,
  • Takeshi Terabayashi,
  • Shigeru Matsuoka,
  • Tomoko Okuma,
  • Sawako Adachi,
  • Tadashi Tomo,
  • Masanori Kawano,
  • Kazuhiro Tanaka,
  • Hiroshi Tsumura,
  • Hirofumi Anai,
  • Toshimasa Ishizaki,
  • Yoshihiro Nishida,
  • Katsuhiro Hanada

DOI
https://doi.org/10.1038/s42003-022-03920-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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Non-camptothecin topoisomerase I inhibitor, Genz, shows potent activity against camptothecin-resistant cells through double-strand break induced cytotoxicity.