Human Vaccines & Immunotherapeutics (Jun 2018)

Cost-effectiveness analysis of routine 13-valent pneumococcal conjugate vaccinations in Chinese infants

  • Hua Zhou,
  • Jinchun He,
  • Bin Wu,
  • Datian Che

DOI
https://doi.org/10.1080/21645515.2018.1438794
Journal volume & issue
Vol. 14, no. 6
pp. 1444 – 1452

Abstract

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Background: This study aimed to evaluate the cost-effectiveness of the 13-valent pneumococcal conjugate vaccine (PCV-13) compared to a no vaccination strategy in Chinese infants. Methods: A Markov process model was developed to examine the outcomes of PCV-13 against a no vaccination strategy using data and assumptions adapted for relevance to China. Outcomes over a lifetime horizon are presented. One-way and probabilistic sensitivity analyses were performed to determine the uncertainty. Results: Compared to no vaccination, a PCV-13 vaccination program would provide a gain of 0.009 additional quality-adjusted life years (QALYs) per subject. From the health care and societal perspectives, the incremental costs per QALY were $20,709 and 18,483, respectively. When herd effect was included, the cost effectiveness of the PCV-13 vaccination strategy was notably improved. The lower price of PCV-13 will improve the cost-effectiveness. Conclusions: The PCV-13 vaccination is likely to be cost-effective at the current Chinese prices and ceiling threshold ($8,382).

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