Nature Communications (Dec 2018)
Integrin CD11b activation drives anti-tumor innate immunity
- Michael C. Schmid,
- Samia Q. Khan,
- Megan M. Kaneda,
- Paulina Pathria,
- Ryan Shepard,
- Tiani L. Louis,
- Sudarshan Anand,
- Gyunghwi Woo,
- Chris Leem,
- M. Hafeez Faridi,
- Terese Geraghty,
- Anugraha Rajagopalan,
- Seema Gupta,
- Mansoor Ahmed,
- Roberto I. Vazquez-Padron,
- David A. Cheresh,
- Vineet Gupta,
- Judith A. Varner
Affiliations
- Michael C. Schmid
- Moores Cancer Center, University of California, San Diego
- Samia Q. Khan
- Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center
- Megan M. Kaneda
- Moores Cancer Center, University of California, San Diego
- Paulina Pathria
- Moores Cancer Center, University of California, San Diego
- Ryan Shepard
- Moores Cancer Center, University of California, San Diego
- Tiani L. Louis
- Moores Cancer Center, University of California, San Diego
- Sudarshan Anand
- Department of Pathology, University of California, San Diego
- Gyunghwi Woo
- Moores Cancer Center, University of California, San Diego
- Chris Leem
- Moores Cancer Center, University of California, San Diego
- M. Hafeez Faridi
- Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center
- Terese Geraghty
- Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center
- Anugraha Rajagopalan
- Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center
- Seema Gupta
- Department of Radiation Oncology, University of Miami Miller School of Medicine
- Mansoor Ahmed
- Department of Radiation Oncology, University of Miami Miller School of Medicine
- Roberto I. Vazquez-Padron
- Department of Surgery, University of Miami Leonard M. Miller School of Medicine
- David A. Cheresh
- Department of Pathology, University of California, San Diego
- Vineet Gupta
- Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center
- Judith A. Varner
- Moores Cancer Center, University of California, San Diego
- DOI
- https://doi.org/10.1038/s41467-018-07387-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.
