Nature Communications (Jul 2022)
[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
- Tharick A. Pascoal,
- Mira Chamoun,
- Elad Lax,
- Hsiao-Ying Wey,
- Monica Shin,
- Kok Pin Ng,
- Min Su Kang,
- Sulantha Mathotaarachchi,
- Andrea L. Benedet,
- Joseph Therriault,
- Firoza Z. Lussier,
- Frederick A. Schroeder,
- Jonathan M. DuBois,
- Baileigh G. Hightower,
- Tonya M. Gilbert,
- Nicole R. Zürcher,
- Changning Wang,
- Robert Hopewell,
- Mallar Chakravarty,
- Melissa Savard,
- Emilie Thomas,
- Sara Mohaddes,
- Sarah Farzin,
- Alyssa Salaciak,
- Stephanie Tullo,
- A. Claudio Cuello,
- Jean-Paul Soucy,
- Gassan Massarweh,
- Heungsun Hwang,
- Eliane Kobayashi,
- Bradley T. Hyman,
- Bradford C. Dickerson,
- Marie-Christine Guiot,
- Moshe Szyf,
- Serge Gauthier,
- Jacob M. Hooker,
- Pedro Rosa-Neto
Affiliations
- Tharick A. Pascoal
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Mira Chamoun
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Elad Lax
- Department of Molecular Biology, Ariel University
- Hsiao-Ying Wey
- Department of Pharmacology and Therapeutics, McGill University
- Monica Shin
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Kok Pin Ng
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Min Su Kang
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Sulantha Mathotaarachchi
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Andrea L. Benedet
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Joseph Therriault
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Firoza Z. Lussier
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Frederick A. Schroeder
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Jonathan M. DuBois
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Baileigh G. Hightower
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Tonya M. Gilbert
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Nicole R. Zürcher
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Changning Wang
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Robert Hopewell
- Montreal Neurological Institute, McGill University
- Mallar Chakravarty
- Departments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre
- Melissa Savard
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Emilie Thomas
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Sara Mohaddes
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Sarah Farzin
- Departments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre
- Alyssa Salaciak
- Departments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre
- Stephanie Tullo
- Departments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging Centre
- A. Claudio Cuello
- Department of Pharmacology and Therapeutics, McGill University
- Jean-Paul Soucy
- Montreal Neurological Institute, McGill University
- Gassan Massarweh
- Montreal Neurological Institute, McGill University
- Heungsun Hwang
- Department of Psychology, McGill University
- Eliane Kobayashi
- Montreal Neurological Institute, McGill University
- Bradley T. Hyman
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Bradford C. Dickerson
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Marie-Christine Guiot
- Montreal Neurological Institute, McGill University
- Moshe Szyf
- Department of Pharmacology and Therapeutics, McGill University
- Serge Gauthier
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- Jacob M. Hooker
- Neurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Pedro Rosa-Neto
- Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill University
- DOI
- https://doi.org/10.1038/s41467-022-30653-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression.
