Briarenolides F and G, New Briarane Diterpenoids from a <em>Briareum</em> sp. Octocoral

Abstract

Two new briarane diterpenoids, briarenolides, F (<strong>1</strong>) and G (<strong>2</strong>), were isolated from an octocoral identified as <em>Briareum</em> sp. The structures of briaranes <strong>1</strong> and <strong>2</strong> were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.

Keywords

• briarenolide
• briarane
• &lt;em&gt;Briareum&lt;/em&gt;
• superoxide anion