Nature Communications (Feb 2021)

Epigraph hemagglutinin vaccine induces broad cross-reactive immunity against swine H3 influenza virus

  • Brianna L. Bullard,
  • Brigette N. Corder,
  • Jennifer DeBeauchamp,
  • Adam Rubrum,
  • Bette Korber,
  • Richard J. Webby,
  • Eric A. Weaver

DOI
https://doi.org/10.1038/s41467-021-21508-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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A range of Influenza vaccines have been linked to induction of adaptive immunity in a number of animal models. Here, the authors utilize a computational design strategy and produce a swine H3 influenza vaccine which shows enhanced efficacy in both murine and porcine infectious disease models.