Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission

Shiheng Liu; Xian Xia; Eric Calvo; Z. Hong Zhou

doi:10.1038/s41467-023-36577-y

Nature Communications (Feb 2023)

Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission

Shiheng Liu,
Xian Xia,
Eric Calvo,
Z. Hong Zhou

Affiliations

Shiheng Liu: Department of Microbiology, Immunology, and Molecular Genetics, University of California
Xian Xia: Department of Microbiology, Immunology, and Molecular Genetics, University of California
Eric Calvo: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Z. Hong Zhou: Department of Microbiology, Immunology, and Molecular Genetics, University of California

DOI: https://doi.org/10.1038/s41467-023-36577-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

Female mosquitoes inject saliva into vertebrate hosts during blood feeding, transmitting mosquito-borne pathogens. Here, cryo-EM of mosquito salivary gland extract uncovers the native SGS1 structure and domains relevant to pathogen transmission.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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