Compensatory cognition in neurological diseases and aging: A review of animal and human studies

Abstract

Specialized individual circuits in the brain are recruited for specific functions. Interestingly, multiple neural circuitries continuously compete with each other to acquire the specialized function. However, the dominant among them compete and become the central neural network for that particular function. For example, the hippocampal principal neural circuitries are the dominant networks among many which are involved in learning processes. But, in the event of damage to the principal circuitry, many times, less dominant networks compensate for the primary network. This review highlights the psychopathologies of functional loss and the aspects of functional recuperation in the absence of the hippocampus.

Keywords

• Amnesia
• Hippocampus
• Learning & memory
• Prefrontal cortex
• Neuronal plasticity
• Neurodegeneration