Frontiers in Microbiology (Oct 2023)
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis
- Qing-Ao Xiao,
- Qing-Ao Xiao,
- Yun-Fei Yang,
- Yun-Fei Yang,
- Lin Chen,
- Lin Chen,
- Ying-Chun Xie,
- Ying-Chun Xie,
- Hai-Tao Li,
- Hai-Tao Li,
- Zhi-Gang Fu,
- Zhi-Gang Fu,
- Qiang Han,
- Qiang Han,
- Jia Qin,
- Jia Qin,
- Jie Tian,
- Jie Tian,
- Wen-Jiang Zhao,
- Wen-Jiang Zhao,
- Fei Cai,
- Fei Cai,
- Yin-Tao Hu,
- Yin-Tao Hu,
- Lin-Feng Ai,
- Lin-Feng Ai,
- Chao Li,
- Chao Li,
- Xu-Ying Chen,
- Xu-Ying Chen,
- Decheng Wang,
- Decheng Wang,
- Yu-Yan Tan,
- Yu-Yan Tan,
- Xuan Xia,
- Xuan Xia,
- Xuan Xia,
- Xiao-Lin Zhang,
- Xiao-Lin Zhang
Affiliations
- Qing-Ao Xiao
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Qing-Ao Xiao
- Yichang Central People's Hospital, Yichang, China
- Yun-Fei Yang
- Yichang Central People's Hospital, Yichang, China
- Yun-Fei Yang
- Department of Surgery of Thyroid and Breast, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Lin Chen
- Yichang Central People's Hospital, Yichang, China
- Lin Chen
- Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Ying-Chun Xie
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Ying-Chun Xie
- Yichang Central People's Hospital, Yichang, China
- Hai-Tao Li
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Hai-Tao Li
- Yichang Central People's Hospital, Yichang, China
- Zhi-Gang Fu
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Zhi-Gang Fu
- Yichang Central People's Hospital, Yichang, China
- Qiang Han
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Qiang Han
- Yichang Central People's Hospital, Yichang, China
- Jia Qin
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Jia Qin
- Yichang Central People's Hospital, Yichang, China
- Jie Tian
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Jie Tian
- Yichang Central People's Hospital, Yichang, China
- Wen-Jiang Zhao
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Wen-Jiang Zhao
- Yichang Central People's Hospital, Yichang, China
- Fei Cai
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Fei Cai
- Yichang Central People's Hospital, Yichang, China
- Yin-Tao Hu
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Yin-Tao Hu
- Yichang Central People's Hospital, Yichang, China
- Lin-Feng Ai
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Lin-Feng Ai
- Yichang Central People's Hospital, Yichang, China
- Chao Li
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Chao Li
- Yichang Central People's Hospital, Yichang, China
- Xu-Ying Chen
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Xu-Ying Chen
- Yichang Central People's Hospital, Yichang, China
- Decheng Wang
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang, China
- Decheng Wang
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Yu-Yan Tan
- Yichang Central People's Hospital, Yichang, China
- Yu-Yan Tan
- Department of Surgery of Thyroid and Breast, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Xuan Xia
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Sciences, China Three Gorges University, Yichang, China
- Xuan Xia
- Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
- Xuan Xia
- Department of Physiology and Pathophysiology, College of Medical School, China Three Gorges University, Yichang, Hubei, China
- Xiao-Lin Zhang
- Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
- Xiao-Lin Zhang
- Yichang Central People's Hospital, Yichang, China
- DOI
- https://doi.org/10.3389/fmicb.2023.1256874
- Journal volume & issue
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Vol. 14
Abstract
Background and aimPrevious studies have reported an association between gut microbiota and cirrhosis. However, the causality between intestinal flora and liver cirrhosis still remains unclear. In this study, bi-directional Mendelian randomization (MR) analysis was used to ascertain the potential causal effect between gut microbes and cirrhosis.MethodsLarge-scale Genome Wide Association Study (GWAS) data of cirrhosis and gut microbes were obtained from FinnGen, Mibiogen consortium, and a GWAS meta-analysis of Alcoholic cirrhosis (ALC). Two-sample MR was performed to determine the causal relationship between gut microbiota and cirrhosis. Furthermore, a bi-directional MR analysis was employed to examine the direction of the causal relations.ResultIn MR analysis, we found that 21 gut microbiotas were potentially associated with cirrhosis. In reverse MR analysis, 11 gut microbiotas displayed potentially associations between genetic liability in the gut microbiome and cirrhosis. We found that the family Lachnospiraceae (OR: 1.59, 95% CI:1.10–2.29) might be harmful in cirrhotic conditions (ICD-10: K74). Furthermore, the genus Erysipelatoclostridium might be a protective factor for cirrhosis (OR:0.55, 95% CI:0.34–0.88) and PBC (OR:0.68, 95% CI:0.52–0.89). Combining the results from the MR analysis and reverse MR analysis, we firstly identified the Genus Butyricicoccus had a bi-directional causal effect on PBC (Forward: OR: 0.37, 95% CI:0.15–0.93; Reverse: OR: 1.03, 95% CI:1.00–1.05).ConclusionWe found a new potential causal effect between cirrhosis and intestinal flora and provided new insights into the role of gut microbiota in the pathological progression of liver cirrhosis.
Keywords
