Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones

Abstract

A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor–acceptor cyclopropane family, has been developed. This method, based on the Corey–Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.

Keywords

• 2-hydroxychalcones
• Corey–Chaykovsky cyclopropanation
• donor–acceptor cyclopropanes