Nature Communications (Sep 2019)
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism
- Tijs Vandoorne,
- Koen Veys,
- Wenting Guo,
- Adria Sicart,
- Katlijn Vints,
- Ann Swijsen,
- Matthieu Moisse,
- Guy Eelen,
- Natalia V. Gounko,
- Laura Fumagalli,
- Raheem Fazal,
- Christine Germeys,
- Annelies Quaegebeur,
- Sarah-Maria Fendt,
- Peter Carmeliet,
- Catherine Verfaillie,
- Philip Van Damme,
- Bart Ghesquière,
- Katrien De Bock,
- Ludo Van Den Bosch
Affiliations
- Tijs Vandoorne
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Koen Veys
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven – University of Leuven
- Wenting Guo
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Adria Sicart
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Katlijn Vints
- VIB, Center for Brain & Disease Research, Electron Microscopy Platform and VIB Bioimaging core facility
- Ann Swijsen
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Matthieu Moisse
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Guy Eelen
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven – University of Leuven
- Natalia V. Gounko
- VIB, Center for Brain & Disease Research, Electron Microscopy Platform and VIB Bioimaging core facility
- Laura Fumagalli
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Raheem Fazal
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Christine Germeys
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Annelies Quaegebeur
- Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust
- Sarah-Maria Fendt
- VIB, VIB-KU Leuven Center for Cancer Biology, Laboratory of Cellular Metabolism and Metabolic Regulation
- Peter Carmeliet
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven – University of Leuven
- Catherine Verfaillie
- Department of Development and Regeneration, Stem Cell Institute, KU Leuven – University of Leuven
- Philip Van Damme
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- Bart Ghesquière
- Department of Oncology, Metabolomics Core Facility, KU Leuven – University of Leuven
- Katrien De Bock
- ETH Zürich, Department of Health Sciences and Technology, Laboratory of Exercise and Health
- Ludo Van Den Bosch
- Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven – University of Leuven
- DOI
- https://doi.org/10.1038/s41467-019-12099-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
While energy metabolism has been repeatedly linked to ALS, motor neuron metabolism remains poorly studied. Here, authors show that human iPSCs rewire specific metabolic routes when they differentiate into functional motor neurons and that ALS-causing mutations in FUS do not affect energy metabolism.
