767 Interferon gamma reduces CAR-T exhaustion and toxicity without compromising therapeutic efficacy in hematologic malignancies

• Marcela Maus,
• Rebecca Larson,
• Irene Scarfò,
• Andrea Schmidts,
• Sonika Vatsa,
• Stefanie Bailey,
• Amanda Bouffard,
• Michael Kann

Affiliations

Marcela Maus

Aff12 grid.25879.310000000419368972Abramson Cancer Center, Dept. of MedicineUniversity of Pennsylvania Perelman School of Medicine Bryn Mawr PA USA

Rebecca Larson

Aff1 Jounce Therapeutics Cambridge MA USA

Irene Scarfò

Aff1 0000 0004 0386 9924grid.32224.35Cellular Immunotherapy ProgramMassachusetts General Hospital Cancer Center and Harvard Medical School 149 13th Street, Room 7.219, Charlestown 02129 Boston MA USA

Andrea Schmidts

Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

Sonika Vatsa

Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

Stefanie Bailey

2Medical University of South Carolina, Charleston, SC, USA

Amanda Bouffard

Massachusetts General Hospital, Charlestown, MA, USA

Michael Kann

Massachusetts General Hospital, Charlestown, MA, USA