Determination of delta aminolevulinic acid levels in urine; a sensitive indicator of lead exposure in construction workers

Abstract

Background: Occupational exposure is a major source for lead poisoning in adults. Lead toxicity disrupts the functions of the digestive system, nervous system, respiratory system, reproductive system, etc. Lead decreases the activity of δ-aminolevulinic acid dehydratase which increases the excretion δ-aminolevulinic acid. The present study is based on this principle by which lead exposure is detected by measuring the urinary δ-ALA levels in construction workers Aim: To estimate the urinary delta aminolevulinic acid levels in construction workers as an index of lead exposure. Materials and methods: The study was done on 55construction workers of age group between 18 years and 50 years with their brief history related to lead exposure. Their urine samples were analysed for δ-ALA by Ehrlich method. Results: According to our observation, it was found that out of the 55 urine samples; 16 samples (29.09%) had urinary δ-ALA levels below reference value (5 to 20 mg/L), 7 workers (17.94%) fell in the dangerous - very high exposure level category (20 or >20 to 40 mg/L). Conclusion: We conclude that there is high prevalence of lead exposure in construction workers in Mumbai, and necessary precautions need to be taken to avoid it.

Keywords

• blood lead levels (bll)
• lead poisoning in construction workers
• urinary delta aminolevulinic acid (δ-ala)