Nature Communications (Jun 2020)
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
- Nicolas Gonzalo Núñez,
- Jimena Tosello Boari,
- Rodrigo Nalio Ramos,
- Wilfrid Richer,
- Nicolas Cagnard,
- Cyrill Dimitri Anderfuhren,
- Leticia Laura Niborski,
- Jeremy Bigot,
- Didier Meseure,
- Philippe De La Rochere,
- Maud Milder,
- Sophie Viel,
- Delphine Loirat,
- Louis Pérol,
- Anne Vincent-Salomon,
- Xavier Sastre-Garau,
- Becher Burkhard,
- Christine Sedlik,
- Olivier Lantz,
- Sebastian Amigorena,
- Eliane Piaggio
Affiliations
- Nicolas Gonzalo Núñez
- Institut Curie, PSL Research University, INSERM U932
- Jimena Tosello Boari
- Institut Curie, PSL Research University, INSERM U932
- Rodrigo Nalio Ramos
- Institut Curie, PSL Research University, INSERM U932
- Wilfrid Richer
- Institut Curie, PSL Research University, INSERM U932
- Nicolas Cagnard
- Paris-Descartes Bioinformatics Platform
- Cyrill Dimitri Anderfuhren
- Institute of Experimental Immunology, University of Zurich, Winterthurerstr. 190
- Leticia Laura Niborski
- Institut Curie, PSL Research University, INSERM U932
- Jeremy Bigot
- Institut Curie, PSL Research University, INSERM U932
- Didier Meseure
- Institut Curie, PSL Research University, Departement de Biologie des Tumeurs
- Philippe De La Rochere
- Institut Curie, PSL Research University, INSERM U932
- Maud Milder
- Institut Curie, PSL Research University, Departement de Biologie des Tumeurs
- Sophie Viel
- Institut Curie, PSL Research University, INSERM U932
- Delphine Loirat
- Institut Curie, PSL Research University, INSERM U932
- Louis Pérol
- Institut Curie, PSL Research University, INSERM U932
- Anne Vincent-Salomon
- Institut Curie, PSL Research University, Departement de Biologie des Tumeurs
- Xavier Sastre-Garau
- Institut Curie, PSL Research University, Departement de Biologie des Tumeurs
- Becher Burkhard
- Institute of Experimental Immunology, University of Zurich, Winterthurerstr. 190
- Christine Sedlik
- Institut Curie, PSL Research University, INSERM U932
- Olivier Lantz
- Institut Curie, PSL Research University, INSERM U932
- Sebastian Amigorena
- Institut Curie, PSL Research University, INSERM U932
- Eliane Piaggio
- Institut Curie, PSL Research University, INSERM U932
- DOI
- https://doi.org/10.1038/s41467-020-17046-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
