Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

José P. Guirao-Abad; Martin Weichert; Ginés Luengo-Gil; Sarah Sze Wah Wong; Vishukumar Aimanianda; Christina Grisham; Nikita Malev; Shivani Reddy; Laura Woollett; David S. Askew

doi:10.1128/mBio.02735-21

mBio (Oct 2021)

Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus

José P. Guirao-Abad,
Martin Weichert,
Ginés Luengo-Gil,
Sarah Sze Wah Wong,
Vishukumar Aimanianda,
Christina Grisham,
Nikita Malev,
Shivani Reddy,
Laura Woollett,
David S. Askew

Affiliations

José P. Guirao-Abad: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Martin Weichert: ORCiD; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Ginés Luengo-Gil: Clinical Analysis and Pathology Department, Group of Molecular Pathology and Pharmacogenetics, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, Cartagena, Spain
Sarah Sze Wah Wong: Institut Pasteur, Molecular Mycology Unit, CNRS, UMR2000, Paris, France
Vishukumar Aimanianda: ORCiD; Institut Pasteur, Molecular Mycology Unit, CNRS, UMR2000, Paris, France
Christina Grisham: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Nikita Malev: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Shivani Reddy: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Laura Woollett: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
David S. Askew: ORCiD; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

DOI: https://doi.org/10.1128/mBio.02735-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study demonstrates that the gene encoding the ER-localized P5-type ATPase SpfA is a downstream target of the UPR in the pathogenic mold A. fumigatusA. fumigatus

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal