Nature Communications (Aug 2016)
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease
- Paul K. Potter,
- Michael R. Bowl,
- Prashanthini Jeyarajan,
- Laura Wisby,
- Andrew Blease,
- Michelle E. Goldsworthy,
- Michelle M. Simon,
- Simon Greenaway,
- Vincent Michel,
- Alun Barnard,
- Carlos Aguilar,
- Thomas Agnew,
- Gareth Banks,
- Andrew Blake,
- Lauren Chessum,
- Joanne Dorning,
- Sara Falcone,
- Laurence Goosey,
- Shelley Harris,
- Andy Haynes,
- Ines Heise,
- Rosie Hillier,
- Tertius Hough,
- Angela Hoslin,
- Marie Hutchison,
- Ruairidh King,
- Saumya Kumar,
- Heena V. Lad,
- Gemma Law,
- Robert E. MacLaren,
- Susan Morse,
- Thomas Nicol,
- Andrew Parker,
- Karen Pickford,
- Siddharth Sethi,
- Becky Starbuck,
- Femke Stelma,
- Michael Cheeseman,
- Sally H. Cross,
- Russell G. Foster,
- Ian J. Jackson,
- Stuart N. Peirson,
- Rajesh V. Thakker,
- Tonia Vincent,
- Cheryl Scudamore,
- Sara Wells,
- Aziz El-Amraoui,
- Christine Petit,
- Abraham Acevedo-Arozena,
- Patrick M. Nolan,
- Roger Cox,
- Anne-Marie Mallon,
- Steve D. M. Brown
Affiliations
- Paul K. Potter
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Michael R. Bowl
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Prashanthini Jeyarajan
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Laura Wisby
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Andrew Blease
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Michelle E. Goldsworthy
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Michelle M. Simon
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Simon Greenaway
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Vincent Michel
- Génétique et Physiologie de l'Audition, Institut Pasteur, INSERM UMR-S 1120, Sorbonne Universités, UPMC Univ Paris 06, Collège de France
- Alun Barnard
- The Nuffield Laboratory of Ophthalmology & NIHR Oxford Biomedical Research Centre, University of Oxford
- Carlos Aguilar
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Thomas Agnew
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Gareth Banks
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Andrew Blake
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Lauren Chessum
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Joanne Dorning
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Sara Falcone
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Laurence Goosey
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Shelley Harris
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Andy Haynes
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Ines Heise
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Rosie Hillier
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Tertius Hough
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Angela Hoslin
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Marie Hutchison
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Ruairidh King
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Saumya Kumar
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Heena V. Lad
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Gemma Law
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Robert E. MacLaren
- The Nuffield Laboratory of Ophthalmology & NIHR Oxford Biomedical Research Centre, University of Oxford
- Susan Morse
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Thomas Nicol
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Andrew Parker
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Karen Pickford
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Siddharth Sethi
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Becky Starbuck
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Femke Stelma
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Michael Cheeseman
- The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
- Sally H. Cross
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Russell G. Foster
- Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of Oxford
- Ian J. Jackson
- The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
- Stuart N. Peirson
- Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of Oxford
- Rajesh V. Thakker
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
- Tonia Vincent
- Nuffield Department of Orthopaedics, Kennedy Institute of Rheumatology, Rheumatology and Musculoskeletal Sciences, University of Oxford
- Cheryl Scudamore
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Sara Wells
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Aziz El-Amraoui
- Génétique et Physiologie de l'Audition, Institut Pasteur, INSERM UMR-S 1120, Sorbonne Universités, UPMC Univ Paris 06, Collège de France
- Christine Petit
- Génétique et Physiologie de l'Audition, Institut Pasteur, INSERM UMR-S 1120, Sorbonne Universités, UPMC Univ Paris 06, Collège de France
- Abraham Acevedo-Arozena
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Patrick M. Nolan
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Roger Cox
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Anne-Marie Mallon
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- Steve D. M. Brown
- MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus
- DOI
- https://doi.org/10.1038/ncomms12444
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing.
