Química Nova (Jan 2010)

Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum

  • Geraldo H. Silva,
  • Camila M. de Oliveira,
  • Helder L. Teles,
  • Vanderlan da S. Bolzani,
  • Angela R. Araujo,
  • Ludwig H. Pfenning,
  • Maria Claudia M. Young,
  • Claudio M. Costa-Neto,
  • Renato Haddad,
  • Marcos N. Eberlin

DOI
https://doi.org/10.1590/S0100-40422010001000006
Journal volume & issue
Vol. 33, no. 10
pp. 2038 – 2041

Abstract

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A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.

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