Nature Communications (Dec 2019)
Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
Abstract
Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome stability.