Nature Communications (Dec 2019)

Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide

  • Olivier Brison,
  • Sami El-Hilali,
  • Dana Azar,
  • Stéphane Koundrioukoff,
  • Mélanie Schmidt,
  • Viola Nähse,
  • Yan Jaszczyszyn,
  • Anne-Marie Lachages,
  • Bernard Dutrillaux,
  • Claude Thermes,
  • Michelle Debatisse,
  • Chun-Long Chen

DOI
https://doi.org/10.1038/s41467-019-13674-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and transcriptional activity correlate with genome stability.