Nature Communications (Feb 2018)

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

  • Yair Razvag,
  • Yair Neve-Oz,
  • Julia Sajman,
  • Meital Reches,
  • Eilon Sherman

DOI
https://doi.org/10.1038/s41467-018-03127-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling.