Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

Francesco Meghini; Torcato Martins; Xavier Tait; Kazuyuki Fujimitsu; Hiroyuki Yamano; David M. Glover; Yuu Kimata

doi:10.1038/ncomms12607

Nature Communications (Aug 2016)

Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

Francesco Meghini,
Torcato Martins,
Xavier Tait,
Kazuyuki Fujimitsu,
Hiroyuki Yamano,
David M. Glover,
Yuu Kimata

Affiliations

Francesco Meghini: Department of Genetics, Cell Cycle Development Group, University of Cambridge
Torcato Martins: Department of Genetics, Cell Cycle Development Group, University of Cambridge
Xavier Tait: Department of Genetics, Cell Cycle Development Group, University of Cambridge
Kazuyuki Fujimitsu: Cell Cycle Control Group, UCL Cancer Institute, University College London
Hiroyuki Yamano: Cell Cycle Control Group, UCL Cancer Institute, University College London
David M. Glover: Department of Genetics, Cell Cycle Genetics Group, University of Cambridge
Yuu Kimata: Department of Genetics, Cell Cycle Development Group, University of Cambridge

DOI: https://doi.org/10.1038/ncomms12607
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 17

Abstract

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The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C activity towards its centrosomal substrate Aurora A.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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