The origin of purulent-septic complications in the obturation ileus

Abstract

Objective. To establish the origin of the purulent complications developing in obturative ileus in experiment. Materials and methods. The experiment was conducted on 24 white rats of the Wistar line, in whom obturative ileus was simulated. Results. The data about dynamical changes of the intestinal wall histostructure above the obstruction and concerning its seeding degree were obtained. In 12 h from the obstruction occurrence the destructive changes in intestinal wall, consisting of mucosal phlegmonous inflammation, occurr, while the bacterial seeding level of the intestinal wall raises from 104 CFU/g of the tissue (the initial) up to 1011 CFU/g. In 36 hours of the ileus persistence the purulent inflammation spreads on submucosal and muscular layers, and translocation of microflora into submucosal layer occurs, the level of microbial seeding of intestinal wall in these terms raises up to 1010-1011 CFU/g of the tissue. Conclusion. Phlegmonous enteritis develops in durable persistence of obturative ileus in intestinal wall, localized above the obstruction. After elimination of obturative ileus, the intestinal lumen and abdominal cavity sanation the main origin of purulent complications persists in intestinal wall above the obstruction.

Keywords

• experimental obturative ileus; purulent-septic complications; purulent enteritis; an acute ileus.