Biomarkers in severe asthma: Identifying the treatable trait

Abstract

Asthma is a chronic condition of bronchial hyper-reactivity associated with inflammation ranges from mild to severe form. It affects 1 – 18% of the population globally and it is estimated that > 300million people in the world have asthma. Of this 5 – 10% have severe asthma. while the proportion of patients suffering from severe are smaller, the morbidity and mortality are higher in this group. With the advances in our understanding of the pathophysiology of asthma there is a need to understand the role of various biomarkers. We live in an era of precision medicine and today there is a clear unmet need to understand targeted therapies. This review aims to raise awareness to the available biomarkers used in clinical practice in India and their role in predicting response to targeted therapies.

Keywords

• biomarkers
• severe asthma
• t2 inflammation