Nature Communications (Jan 2022)
Lipidomic profiling of human serum enables detection of pancreatic cancer
- Denise Wolrab,
- Robert Jirásko,
- Eva Cífková,
- Marcus Höring,
- Ding Mei,
- Michaela Chocholoušková,
- Ondřej Peterka,
- Jakub Idkowiak,
- Tereza Hrnčiarová,
- Ladislav Kuchař,
- Robert Ahrends,
- Radana Brumarová,
- David Friedecký,
- Gabriel Vivo-Truyols,
- Pavel Škrha,
- Jan Škrha,
- Radek Kučera,
- Bohuslav Melichar,
- Gerhard Liebisch,
- Ralph Burkhardt,
- Markus R. Wenk,
- Amaury Cazenave-Gassiot,
- Petr Karásek,
- Ivo Novotný,
- Kristína Greplová,
- Roman Hrstka,
- Michal Holčapek
Affiliations
- Denise Wolrab
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Robert Jirásko
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Eva Cífková
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Marcus Höring
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg
- Ding Mei
- Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore
- Michaela Chocholoušková
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Ondřej Peterka
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Jakub Idkowiak
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Tereza Hrnčiarová
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- Ladislav Kuchař
- Research Unit for Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague
- Robert Ahrends
- Department of Analytical Chemistry, University of Vienna
- Radana Brumarová
- Palacký University Olomouc, Institute of Molecular and Translational Medicine
- David Friedecký
- Palacký University Olomouc, Institute of Molecular and Translational Medicine
- Gabriel Vivo-Truyols
- Tecnometrix
- Pavel Škrha
- Third Faculty of Medicine, Charles University
- Jan Škrha
- 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University
- Radek Kučera
- Department of Immunochemistry Diagnostics, University Hospital in Pilsen
- Bohuslav Melichar
- Department of Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital
- Gerhard Liebisch
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg
- Ralph Burkhardt
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg
- Markus R. Wenk
- Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore
- Amaury Cazenave-Gassiot
- Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore
- Petr Karásek
- Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute
- Ivo Novotný
- Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute
- Kristína Greplová
- Faculty of Medicine, Masaryk University
- Roman Hrstka
- Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute
- Michal Holčapek
- Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice
- DOI
- https://doi.org/10.1038/s41467-021-27765-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Patients with pancreatic cancer have a poor prognosis, more research is required to identify the disease at an earlier stage. Here, the authors use lipid profiles of blood samples and show that they can distinguish patients with pancreatic cancer from healthy controls.
