Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases
Dong Li,
Jie Pan,
Shuyu Xu,
Shiying Fu,
Chengchao Chu,
Gang Liu
Affiliations
Dong Li
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, China
Jie Pan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, China
Shuyu Xu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, China
Shiying Fu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, China
Chengchao Chu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, China
Gang Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, China
Recently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific targeting to biological tissues, showing a higher imaging signal-to-background ratio and a lower detection limit. Therefore, it is of great significance to utilize disease-associated endogenous stimuli (such as pH values, enzyme existence, hypoxia condition and so on) to activate the NIR-II probes and achieve switchable fluorescent signals for specific deep bioimaging. This review introduces recent strategies and mechanisms for activatable NIR-II fluorescent probes and their applications in biosensing and bioimaging. Moreover, the potential challenges and perspectives of activatable NIR-II fluorescent probes are also discussed.
