The beneficial impact of plant-based fiber-enriched diets on hepatic enzymes for reduction of cardiovascular diseases in a rat model

Abstract

Summary: Background and Aims: Cardiovascular diseases (CVD) and their complexity, intimately linked to diet, are substantial public health issues. Hepatic enzymes are liver function parameters, also referred to as hepatic objects, and are groups of blood tests that provide information about the state of a patient's liver. To investigate the potential effects of a plant-based high-fiber enrich diet on improving hepatic enzymes in growing rat models to prevent and manage CVD. The current investigation developed a fiber-enriched diet and compared it with control, high-fat, and other formulated diets on rat models. Methods: About 36 Long Evan rats were fed with two experimental phases for 12 weeks (each phase lasting six weeks). After each phase, half of the rats were sacrificed for serum collection to measure biochemical parameters and statistical analysis. Results: High fat 65% + high fiber 35% diet group showed ALP, ALT, and AST levels significantly (P<0.05) lowest in both (six and twelve weeks) treatment when comparing with control, high-fat, and all other developed groups. Also, low-fiber and high-fiber diets resulted in maximization of liver enzymes. Conclusions: This investigation visualized that a high-fat 65% + high-fiber 35% diet may have superior advantages as a viable diet therapy for reducing cardiovascular illness and managing abnormal liver enzymes.

Keywords

• BMI
• CVD
• Hepatic enzymes
• High-fiber diet
• Plant-based diet